Impacts of coexisting bronchial asthma on severe exacerbations in mild-to-moderate COPD: results from a national database.

نویسندگان

  • Hyun Lee
  • Chin Kook Rhee
  • Byung-Jae Lee
  • Dong-Chull Choi
  • Jee-Ae Kim
  • Sang Hyun Kim
  • Yoolwon Jeong
  • Tae-Hyung Kim
  • Gyu Rak Chon
  • Ki-Suck Jung
  • Sang Haak Lee
  • David Price
  • Kwang Ha Yoo
  • Hye Yun Park
چکیده

BACKGROUND Acute exacerbations are major drivers of COPD deterioration. However, limited data are available for the prevalence of severe exacerbations and impact of asthma on severe exacerbations, especially in patients with mild-to-moderate COPD. METHODS Patients with mild-to-moderate COPD (≥40 years) were extracted from Korean National Health and Nutrition Examination Survey data (2007-2012) and were linked to the national health insurance reimbursement database to obtain medical service utilization records. RESULTS Of the 2,397 patients with mild-to-moderate COPD, 111 (4.6%) had severe exacerbations over the 6 years (0.012/person-year). Severe exacerbations were more frequent in the COPD patients with concomitant self-reported physician-diagnosed asthma compared with only COPD patients (P<0.001). A multiple logistic regression presented that asthma was an independent risk factor of severe exacerbations in patients with mild-to-moderate COPD regardless of adjustment for all possible confounding factors (adjusted odds ratio, 1.67; 95% confidence interval, 1.002-2.77, P=0.049). In addition, age, female, poor lung function, use of inhalers, and low EuroQoL five dimensions questionnaire index values were independently associated with severe exacerbation in patients with mild-to-moderate COPD. CONCLUSION In this population-based study, the prevalence of severe exacerbations in patients with mild-to-moderate COPD was relatively low, compared with previous clinical interventional studies. Coexisting asthma significantly impacted the frequency of severe exacerbations in patients with mild-to-moderate COPD, suggesting application of an exacerbation preventive strategy in these patients.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Determination the Role of Endothelial Cell-Specific Molecule-1(ESM-1) in Childhood Bronchial Asthma

  Background Endothelial Cell-Specific Molecule-1 (ESM-1) is a 50 kDa soluble proteoglycan that is produced mainly the vascular endothelial cells of the kidney and lung. It is produced by the effects of proangiogenic and pro-inflammatory cytokines, and it indicates activation and dysfunction of the vascular endothelium. We aimed to detect the role of ESM-1 in childre...

متن کامل

A Study on Clinical Efficacy of Lepidium Sativum Seeds in Treatment of Bronchial Asthma

The present investigation was carried out to determine the efficacy and safety of Lepidium sativum (L. sativum) (Garden Cress, Fam: Cruciferae) in patients of bronchial asthma. L. sativum seed powder was given at a dose of 1 gm thrice a day orally to 30 patients of either sex in the range of 15-80 years with mild to moderate bronchial asthma without any concurrent medication. The respiratory fu...

متن کامل

Phospho-p38 MAPK expression in COPD patients and asthmatics and in challenged bronchial epithelium.

BACKGROUND The role of mitogen-activated protein kinases (MAPK) in regulating the inflammatory response in the airways of patients with chronic obstructive pulmonary disease (COPD) and asthmatic patients is unclear. OBJECTIVES To investigate the expression of activated MAPK in lungs of COPD patients and in bronchial biopsies of asthmatic patients and to study MAPK expression in bronchial epit...

متن کامل

Study of pattern of drug treatment in patients with exacerbations of bronchial asthma in an emergency ward of a teaching hospital: A prospective, cross sectional study

Exacerbations of bronchial asthma is one of the common presenting complaints affecting all age groups. There has been a recent increase in the incidence of asthma with a parallel increase in the number of drugs available for its treatment. The present study was aimed at evaluating prescribing pattern of medications in exacerbations of bronchial asthma and to compare it with National Asthma Educ...

متن کامل

Evaluation of Omeprazole in the Treatment of Moderate to Severe Persistent Asthma in Children

Background and Objective: Asthma is the most common chronic disease of childhood. The disease is caused by a temporary blockage of airflow due to chronic inflammation of the airways . One of the conditions that often occur with asthma and exacerbate disease, is gastroesophageal reflux. The aim of this study is to evaluate the role of acid suppressing therapy in patients with refractory asthma...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • International journal of chronic obstructive pulmonary disease

دوره 11  شماره 

صفحات  -

تاریخ انتشار 2016